abstract：BACKGROUND AND AIMS:Inflammatory bowel disease (IBD) has many characteristics of autoimmune diseases. Sensorineural hearing loss has been reported in many autoimmune diseases. Little is known about hearing loss in patients with IBD. METHODS:A prospective blinded comparative study was conducted over a 3-year period. IB...

journal_title：Digestive diseases and sciences

authors： Wengrower D,Koslowsky B,Peleg U,Mazuz B,Cohen L,Ben-David A,Gross M,Goldin E,Shaul C

更新日期：2016-07-01 00:00:00

abstract：:Barrett's esophagus (BE) is intestinal metaplasia of the lower esophagus and a precursor lesion for esophageal adenocarcinoma (EAC). Both are important health issues as they have rising incidences in the Western world. Improving the management of BE relies on understanding the underlying biology of this disease, but t...

journal_title：Digestive diseases and sciences

authors： To H,Clemons NJ,Duong CP,Trainer AH,Phillips WA

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:The role of cannabinoids in gastrointestinal diseases is controversial and of great interest, yet their use in patients has not been critically examined. AIM:To determine the prevalence and effects of cannabis abuse on healthcare utilization, as measured by emergency department (ED) visits, in a large, tert...

journal_title：Digestive diseases and sciences

authors： Gubatan J,Staller K,Barshop K,Kuo B

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Gastric intestinal metaplasia (GIM) is an accepted pathologic precursor to gastric adenocarcinoma (GAC). While surveillance of GIM in Europe and Asia is common, only limited recommendations related to endoscopic surveillance of GIM exist in the United States. AIM:To understand the clinical practice patterns...

journal_title：Digestive diseases and sciences

authors： Vance RB Jr,Kubiliun N,Dunbar KB

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND AND AIM:Postoperative infection is not uncommon after hepatectomy. This study assessed the effectiveness of preoperative antibiotic prophylaxis in elective hepatectomy in a randomized clinical trial setting. METHODS:A total of 120 patients who were scheduled to undergo elective hepatectomy were equally rand...

journal_title：Digestive diseases and sciences

authors： Zhou YM,Chen ZY,Li XD,Xu DH,Su X,Li B

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Both colorectal neoplasms and atherosclerosis can be induced by common visceral fat accumulation. However, the association between these diseases at the advanced stage, colorectal cancer and cardiovascular/cerebrovascular diseases, has not been elucidated. AIMS:This study aimed to investigate the associatio...

journal_title：Digestive diseases and sciences

authors： Yamaji Y,Yasunaga H,Hirata Y,Yamada A,Yoshida S,Horiguchi H,Fushimi K,Koike K

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Gastric acidification inhibits motilin-induced gastric phase III contractions. However, the underlying mechanism has not been thoroughly investigated. Here, we studied the inhibitory mechanism by gastric acidification on motilin-induced contraction in Suncus murinus (S. murinus). METHODS:We measured interdi...

journal_title：Digestive diseases and sciences

authors： Yoshimura M,Mikami T,Kuroda K,Nishida M,Ito K,Mondal A,Koyama K,Jogahara T,Sakata I,Sakai T

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Esophageal stricture is one of the serious adverse events following endoscopic submucosal dissection (ESD). However, optimum preventive techniques are still lacking. AIMS:Our primary objective was to evaluate the incidence of post-ESD esophageal stricture with the application of carboxymethyl cellulose (CMC...

journal_title：Digestive diseases and sciences

authors： Lua GW,Tang J,Liu F,Li ZS

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Total parenteral nutrition (TPN), a necessary treatment for patients who cannot receive enteral nutrition, is associated with infectious complications due in part to a loss of intestinal epithelial barrier function (EBF). Using a mouse model of TPN, with enteral nutrient deprivation, we previously demonstrat...

journal_title：Digestive diseases and sciences

authors： Demehri FR,Krug SM,Feng Y,Lee IF,Schulzke JD,Teitelbaum DH

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Birth characteristics, including weight and gestational age, may be associated with risk of Barrett's esophagus (BE), the only known precursor for esophageal adenocarcinoma; however, data are limited. AIMS:To examine associations between various birth characteristics and BE, and whether these associations a...

journal_title：Digestive diseases and sciences

authors： Shiota S,El-Serag HB,Thrift AP

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:DNA methylation mainly affects tumor suppressor genes in the development of hepatocellular carcinoma (HCC). However, sera methylation of specific genes in hepatitis B virus (HBV)-related HCC remains unknown. AIMS:The purpose of this study was to identify methylation frequencies of sera E-cadherin (CDH1), DN...

journal_title：Digestive diseases and sciences

authors： Dou CY,Fan YC,Cao CJ,Yang Y,Wang K

更新日期：2016-04-01 00:00:00

abstract：:Patients with long-standing ulcerative colitis (UC) or Crohn's colitis are at increased risk of developing colorectal cancer (CRC). Given that most cases of CRC are thought to arise from dysplasia, previous guidelines have recommended endoscopic surveillance with random biopsies obtained from all segments of the colon...

journal_title：Digestive diseases and sciences

authors： Sengupta N,Yee E,Feuerstein JD

更新日期：2016-04-01 00:00:00

abstract：:Local or national policy, patients' preferences, safety and/or economic concerns, or reimbursement issues may dictate stopping drug in inflammatory bowel diseases (IBD) patients. Sustained deep remission is an important predictor of a better outcome after anti-tumor necrosis (TNF) factor therapy discontinuation, inclu...

journal_title：Digestive diseases and sciences

authors： Williet N,Paul S,Peyrin-Biroulet L,Roblin X

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Esophageal epithelial microRNAs may be used to diagnose Barrett's esophagus (BE) and possibly monitor its progression to esophageal adenocarcinoma (EAC). AIMS:We reviewed studies that have investigated this to identify microRNAs with high biomarker potential for screening and disease monitoring in BE. METH...

journal_title：Digestive diseases and sciences

authors： Mallick R,Patnaik SK,Wani S,Bansal A

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Activation of the transcription factor NF-κB and expression of pro-inflammatory mediators have been considered as major events of acute pancreatitis (AP). Karyopherin alpha 2 (KPNA2), a member of the importin α family, reportedly modulates p65 subcellular localization. AIM:This study aimed to investigate th...

journal_title：Digestive diseases and sciences

authors： Cai Y,Shen Y,Gao L,Chen M,Xiao M,Huang Z,Zhang D

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Data on ERCP nurses and associate (ERCP-NA) training and comfort are lacking. Healthcare industry representative (HCIR) influence may be greater in low-volume units (LVUs) due to decreased procedure and device familiarity. AIM:The aim of this study was to compare ERCP-NA training, safety, and HCIR relations...

journal_title：Digestive diseases and sciences

authors： Keswani RN,Malpas P,Lynch SE,Coté GA

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:The pentapeptide ghrelin agonist, relamorelin, accelerates colonic transit in patients with chronic constipation (CC). In a murine model, relamorelin decreased excitability of colonic circular smooth muscle cells and colonic intraluminal pressure. AIM:To determine short-term effects of relamorelin on coloni...

journal_title：Digestive diseases and sciences

authors： Acosta A,Camilleri M,Busciglio I,Boldingh A,Nelson AD,Burton D

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Much of the economic burden of Crohn's disease (CD) is related to surgery. Twenty percent of patients with CD have isolated colonic disease. While permanent end ileostomy (EI) is generally the procedure of choice for patients with refractory CD colitis, single-center experiences suggest that restorative proc...

journal_title：Digestive diseases and sciences

authors： Taleban S,Van Oijen MG,Vasiliauskas EA,Fleshner PR,Shen B,Ippoliti AF,Targan SR,Melmed GY

更新日期：2016-02-01 00:00:00

abstract：:Hereditary type 2 diabetes mellitus is a risk factor for chronic liver disease, and ~30 % of patients with liver cirrhosis develop diabetes. Diabetes mellitus has been associated with cirrhotic and non-cirrhotic hepatitis C virus liver infection, can aggravate the course the liver infection, and can induce a lower sus...

journal_title：Digestive diseases and sciences

authors： García-Compeán D,González-González JA,Lavalle-González FJ,González-Moreno EI,Villarreal-Pérez JZ,Maldonado-Garza HJ

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND AND AIMS:The detailed risk factors such as bleeding pattern, comorbidities, and medication usage of patients with obscure gastrointestinal bleeding (OGIB) are largely unknown. We evaluated the risk factors related to ulcerative and vascular lesions of the small intestine diagnosed by capsule endoscopy or bal...

journal_title：Digestive diseases and sciences

authors： Okamoto J,Tominaga K,Sugimori S,Kato K,Minamino H,Ominami M,Fukunaga S,Nagami Y,Kamata N,Yamagami H,Tanigawa T,Shiba M,Watanabe T,Fujiwara Y,Arakawa T

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) is a chronic, debilitating condition with high emergency department (ED) utilization. We aimed to investigate the utilization patterns of ED by IBD patients and measure hospitalization and surgical rates following ED visits. METHODS:We conducted a cross-sectional study of ad...

journal_title：Digestive diseases and sciences

authors： Gajendran M,Umapathy C,Loganathan P,Hashash JG,Koutroubakis IE,Binion DG

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:The relation of gastrointestinal (GI) complaints to IgE-mediated allergy is not well understood. Increased numbers of "IgE-armed" mast cells have been observed in duodenal mucosa of patients with functional GI complaints. AIMS:To explore whether total IgE and atopic sensitization were associated with functi...

journal_title：Digestive diseases and sciences

authors： Vara EJ,Svanes C,Skorge TD,Berstad A,Florvaag E,Jarvis D,Omenaas E,Waatevik M,Johannessen A,Lied GA

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND AND AIM:Atelectasis is one of the pulmonary complications associated with anesthesia. Little is known about atelectasis following endoscopic procedures under deep sedation. This study evaluated the frequency, risk factors, and clinical course of atelectasis after endoscopic resection. METHODS:A total of 349...

journal_title：Digestive diseases and sciences

authors： Choe JW,Jung SW,Song JK,Shim E,Choo JY,Kim SY,Hyun JJ,Koo JS,Yim HJ,Lee SW

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:To date, there are no studies reporting an association between vitamin D and Barrett's esophagus (BE), the precursor for esophageal adenocarcinoma (EAC). AIMS:Our aim was to study the association between serum 25-hydroxyvitamin D (25(OH)D) levels and prevalence and incidence of dysplasia/EAC in BE. METHODS...

journal_title：Digestive diseases and sciences

authors： Thota PN,Kistangari G,Singh P,Cummings L,Hajifathalian K,Lopez R,Sanaka MR

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND AND AIM:Aberrant methylation of specific genes is frequent event in hepatocellular carcinoma (HCC). Our present study aims to explore the methylation levels of acid phosphatase locus 1 (ACP1), bone morphogenetic protein 4 (BMP4), and testis-specific protein, Y-encoded-like 5 (TSPYL5) and their potential clin...

journal_title：Digestive diseases and sciences

authors： Qiu X,Hu B,Huang Y,Deng Y,Wang X,Zheng F

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:To evaluate rate, recurrence, and predictors of gastrointestinal bleeding (GIB) and impact of endoscopy in left ventricular assist device (LVAD) patients. METHODS:This is a cohort study of all patients who received the current-generation continuous-flow HeartMate II LVAD from 2005 to 2013 at our institution...

journal_title：Digestive diseases and sciences

authors： Jabbar HR,Abbas A,Ahmed M,Klodell CT Jr,Chang M,Dai Y,Draganov PV

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Regenerating islet-derived 3 (Reg3) is abnormally expressed in several human digestive system diseases, including chronic pancreatitis (CP) and pancreatic cancer (PC). AIM:The purpose of this study was to clarify the mechanism of the enhanced expression of Reg3 in inflammation-induced PC. METHODS:C57BL/6 m...

journal_title：Digestive diseases and sciences

authors： Yin G,Du J,Cao H,Liu X,Xu Q,Xiang M

更新日期：2015-12-01 00:00:00

abstract：:Hepatitis B virus (HBV) infection is a major etiology of chronic liver disease worldwide. In the past decade, nonalcoholic fatty liver disease (NAFLD) has emerged as a common liver disorder in general population. Accordingly, the patient number of chronic hepatitis B (CHB) concomitant with NAFLD grows rapidly. The pre...

journal_title：Digestive diseases and sciences

authors： Lin CW,Huang XL,Liu HL,Wang Y

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:To compare the Rosemont criteria, which are graded features chosen by experts in 2007, versus the conventional criteria, which require ≥ 3-5 of the 9 features that are "counted as equal," for the diagnosis of chronic pancreatitis by EUS. METHODS:This is a retrospective cohort study. EUS examinations were sco...

journal_title：Digestive diseases and sciences

authors： D'Souza SL,Anderson MA,Korsnes SJ,Elmunzer BJ,Piraka C,Menees S,Wamsteker EJ,Kwon RS,Scheiman JM,Elta GH

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Despite accumulating data on the pathogenesis of eosinophilic esophagitis, not much is known about risk factors for the development of the disease. The role of factors such as smoking, breastfeeding, early antibiotic exposure and other factors that have been associated with other allergic diseases has not be...

journal_title：Digestive diseases and sciences

authors： Slae M,Persad R,Leung AJ,Gabr R,Brocks D,Huynh HQ

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:The outcomes of infliximab dose escalation in ulcerative colitis (UC) have not been well evaluated. AIMS:To assess the short- and long-term outcomes of infliximab dose escalation in a cohort of patients with UC. METHODS:This was a multicenter, retrospective, cohort study. All consecutive UC patients who ha...

journal_title：Digestive diseases and sciences

authors： Taxonera C,Barreiro-de Acosta M,Calvo M,Saro C,Bastida G,Martín-Arranz MD,Gisbert JP,García-Sánchez V,Marín-Jiménez I,Bermejo F,Chaparro M,Ponferrada Á,Martínez-Montiel MP,Pajares R,de Gracia C,Olivares D,Alba C,Mendoza

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Lysyl oxidase (LOX) is frequently overexpressed in a variety of malignancies and involved in tumor invasion and metastasis. Furthermore, it has been shown that LOX is closely related to vascular endothelial growth factor (VEGF). AIMS:In this study, we aimed to investigate the exact role of LOX and the corre...

journal_title：Digestive diseases and sciences

authors： Zhu J,Huang S,Wu G,Huang C,Li X,Chen Z,Zhao L,Zhao Y

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Barrett's esophagus (BE) is characterized by a distinct Th2-predominant cytokine profile. However, antigens that shift the immune response toward the Th2 profile are unknown. AIM:We examined the effects of rebamipide on the esophageal microbiome and BE development in a rat model. METHODS:BE was induced by ...

journal_title：Digestive diseases and sciences

authors： Kohata Y,Nakahara K,Tanigawa T,Yamagami H,Shiba M,Watanabe T,Tominaga K,Fujiwara Y,Arakawa T

更新日期：2015-09-01 00:00:00

abstract：AIM:Although Ebola virus infection (EVI) clinically presents with common, prominent, gastroenterologic manifestations, this subject has not been previously reviewed. This work critically and comprehensively reviews this subject. METHODS:This study is a comprehensive literature review generated by computerized search o...

journal_title：Digestive diseases and sciences

authors： Sharma N,Cappell MS

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Chronic megacolon is a rare disease of the colonic motor function characterized by a permanent increase in colonic diameter. METHODS:We reviewed electronic medical records of all patients diagnosed with chronic megacolon from 1999 to 2014 at Mayo Clinic. Our aim was to summarize clinical and motility featur...

journal_title：Digestive diseases and sciences

authors： O'Dwyer RH,Acosta A,Camilleri M,Burton D,Busciglio I,Bharucha AE

更新日期：2015-08-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is an important etiologic factor in the development of colorectal cancer (CRC). The risk of CRC begins to increase 8 or 10 years after the diagnosis of IBD. This type of cancer is called colitis-associated CRC (CA-CRC). The molecular pathogenesis of inflammatory epithelium might play a...

journal_title：Digestive diseases and sciences

authors： Yashiro M

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:The heterogeneous patterns and trends in tobacco consumption contribute to regional and gender differences in the burden of gastric cancer attributable to smoking. AIMS:To estimate the proportion and absolute number of gastric cancer cases that can be attributed to smoking in different countries, in 2012 an...

journal_title：Digestive diseases and sciences

authors： Peleteiro B,Castro C,Morais S,Ferro A,Lunet N

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:It is unclear whether the quality of bowel preparation affects colonoscopic detection of non-polypoid colorectal neoplasms (NP-CRNs). AIM:To evaluate the impact of bowel-cleansing quality on detection of NP-CRNs. METHODS:We performed a retrospective analysis of asymptomatic screening colonoscopy cases afte...

journal_title：Digestive diseases and sciences

authors： Oh CH,Lee CK,Kim JW,Shim JJ,Jang JY

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Vitamin D deficiency is common in patients with inflammatory bowel diseases. The vitamin D receptor (VDR) is a nuclear hormone receptor mediating the activity of vitamin D hormone. Our previous studies showed that intestinal epithelial VDR signaling inhibits colitis by protecting the mucosal epithelial barri...

journal_title：Digestive diseases and sciences

authors： Golan MA,Liu W,Shi Y,Chen L,Wang J,Liu T,Li YC

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:The use of volatile organic compounds (VOCs) in bile was recently studied and appeared promising for diagnosis of malignancy. Noninvasive diagnosis of malignant biliary strictures by using VOCs in urine has not been studied. AIM:To identify potential VOCs in urine to diagnose malignant biliary strictures. ...

journal_title：Digestive diseases and sciences

authors： Navaneethan U,Parsi MA,Lourdusamy D,Grove D,Sanaka MR,Hammel JP,Vargo JJ,Dweik RA

更新日期：2015-07-01 00:00:00